National Union of Journalists members working at Newsquest in York start balloting for action today.
The ballot comes after the company put a number of positions on the Gazette and Herald at risk of redundancy, including the editor.
Also at risk are the deputy editor, internet editor, digital communications editor, newsroom assistant and deputy sports editor.
The title has a weekly circulation of around 9,000 and a cover price of £1.
According to the NUJ, Newsquest plans to transfer jobs including chief sub, night production editor, features editor and communities editor to Bradford.
Chris Morley, NUJ Northern and Midlands organiser, said: "Our members in York are incensed that yet again the company is looking to force its journalists out of their livelihoods in yet more knee-jerk cuts.
"They want to put a marker down to the company that it is going too far and that it risks destroying the very essence of its titles as sources of trusted, quality, local news.
"There is already a backlash in the community at news of these cuts and we know our members' stand will be greatly supported by the city they serve."