Fourteen editorial staff at The People are being made redundant as the Trinity Mirror-owned Sunday title continues to lose sales at a rapid rate.
Job cuts are being made across the main paper and on its TV magazine Take It Easy.
Most of the jobs to go are journalists with “one or two” expected to be administrative positions.
The People, which has taken successive circulation drops throughout the year, currently employs around 100 editorial staff.
A Trinty Mirror spokesman said the People's cuts were not a part of the company's review of all its buinesses.
The review, announced in August followed a downturn of operating profits, which fell 14.3 per cent year on year in the six months to July 2006 to £110 million on turnover down 2.2 per cent to £566.6m.
In an email to staff MGN managing director Richard Webb said: "In an incredibly competitive market The People has been battling to hold its readership and has successfully maintained its position as one of our key titles.
"However, the marketplace has become increasingly difficult, driven by an unprecedented downturn in advertising.
In order to preserve The People's long-term competitiveness we need to make sure the resources we direct into the newspaper are used to maximum effect.
"The editorial and commercial management teams have been working to identify areas where we can make savings, which unfortunately means we are proposing a number of editorial redundancies on The People, the closure of its office in Ireland and the merger of staff from Take it Easy magazine into the main paper.
"In total there are likely to be in the region of 14 redundancies.
The Editor is meeting with heads of department today to outline the proposals in detail. Consultation with individuals who are affected begins immediately.
"We appreciate that today's announcement will be unsettling for staff on The People but it is imperative we act now in order to secure the title's position in the Sunday market.
In September 2004 16 journalists were made redundant at the People in order – Trinity Mirror said – so the paper would have a bigger budget to spent on marketing. In 2002 the People cut 12 jobs.
ABC circulation figures for September show the people down 10.13 per cent year-on-year to 822,014. This was the worst year-on-year drop of any UK national newspaper.